The association between a polygenic Alzheimer score and cortical thickness in clinically normal subjectsa

1 The association between a polygenic Alzheimer score and cortical thickness in clinically normal subjects Mert R. Sabuncu, PhD; Randy L. Buckner, PhD; Jordan W. Smoller, MD, ScD; Phil Hyoun Lee, PhD; Bruce Fischl, PhD; and Reisa A. Sperling, MD; for the Alzheimer’s Disease Neuroimaging Initiative Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, 02129, USA Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA Department of Psychology and Center for Brain Science, Harvard University, Cambridge, MA, 02128, USA; and Howard Hughes Medical Institute, Cambridge, MA, 02128, USA Center for Human Genetic Research, Massachusetts General Hospital, Richard B. Simches Research Center, Boston, MA 02114 Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women’s Hospital, Boston, 02115, MA, USA and Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA